Ketamine has been demonstrated to play a fundamental role in the treatment of treatment-resistant depression; it has been shown to be effective in patients as it reduces depressive symptoms and suicidal ideation within hours after administration [source].
Symptoms associated with PTSD may be caused by a lack of synaptic connectivity in the brain; ketamine may restore synaptic connectivity and reverse the effects of stress [source].
Multiple studies suggest that ketamine may improve the ability to establish and maintain abstinence in substance use disorders [source].
Ketamine has been used to alleviate chronic pain that has a neuropathic component; it may also prevent the occurrence of chronic pain states following surgery [source].
Ketamine and other glutamatergic agents may offer novel strategies for the management of treatment-resistant patients with anxious symptoms [source].
Using multiple infusions of ketamine in bipolar depression can produce rapid and consistent effects, and may improve mood level and stability, cognition, and sleep [source].
of people with depression do not recover fully on antidepressant medication.
of those receiving a ketamine treatment experience symptom relief within the following 24 hours.
“Ketamine, given intravenously, might be the most important breakthrough in antidepressant treatment in decades.”
Thomas Insel, Former Director
National Institute for Mental Health (NIMH)